反应详情

温度

105 °C

474 parts of anhydrous sorbitol were melted in a stainless steel reactor equipped with agitation means and heated to a temperature of 105° C. The molten sorbitol was agitated at a speed of 100 r.p.m. to create a vortex and thereafter 25 parts of cimetidine (melting point 141°-143° C.) were added to the vortex slowly to avoid forming lumps. After complete addition, the melt was agitated for an additional 10 minutes. This melt was transferred to a Sigma blade mixer heated at 90° C. with hot water and agitated at 18 r.p.m. After 1 minute of mixing, 1% crystalline sorbitol seed fines (less than 325 mesh) were slowly added over the surface of the agitating melt to achieve a uniform dispersion of the seeds in the melt in order to initiate a rapid crystallization in the mixer. When the crystallizing mass achieved a dough-like consistency in the mixer, it was removed and placed on a tray, spread out and placed in an oven at 50° C. for 10 hours until it was fully crystallized. The crystalline mass was cooled and aggregates of the material were ground in a laboratory Waring blender (medium speed, 5 seconds), then screened to collect a -40/+100 mesh fraction.

1. customequipped with agitation means
2. customto avoid forming lumps
3. additionAfter complete addition
4. stirringagitated at 18 r.p.m
5. additionAfter 1 minute of mixing
6. customa rapid crystallization in the mixer
7. customwas removed
8. waitplaced in an oven at 50° C. for 10 hours until it
9. customwas fully crystallized
10. temperatureThe crystalline mass was cooled
11. customwere ground in a laboratory Waring blender (medium speed, 5 seconds)
12. customto collect a -40/+100 mesh fraction