Chloroform → 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

HRID 146134Notes

Reaction equation

HRID 146134 reaction equation
[CH3:1][O:2][c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][c:9](=[O:29])[n:10]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]3)[c:11]2[cH:12]1.[CH:30]([Cl:31])([Cl:32])[Cl:33].[OH:34][C:35]([C:36]([F:37])([F:38])[F:39])=[O:40]>>[CH3:1][O:2][c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][c:9](=[O:29])[n:10]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[c:11]2[cH:12]1

Participants

4

Reactant 3

HCID 6212ChloroformHCID 6422Trifluoroacetic acidHCID 57815396tert-butyl (1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

Product 1

HCID 578151881-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-60ffab5bd7f34c85aa3ea9ff1de6d26a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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