Diethylamine → HCID 19980557, compound

HRID 1461366Notes

Reaction equation

HRID 1461366 reaction equation
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].Cl[C:7]1[S:8][C:9]([N+:13]([O-:15])=[O:14])=[C:10]([Cl:12])[N:11]=1>O1CCOCC1>[CH2:1]([N:3]([CH2:4][CH3:5])[C:7]1[S:8][C:9]([N+:13]([O-:15])=[O:14])=[C:10]([Cl:12])[N:11]=1)[CH3:2]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 138518172,4-Dichloro-5-nitro-1,3-thiazole

Product 1

HCID 19980557HCID 19980557, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

146 g (2 mols) of diethylamine are added dropwise to a solution of 199 g (1 mol) of 2,4-dichloro-5-nitrothiazole in 1 l of dioxane at 20° C. to 30° C. in the course of about 2 hours. After the mixture has been left to stand overnight at room temperature, it is stirred in 8 l of icewater and the precipitate is filtered off, washed with water and dried. 216 g (91.7% of theory) of 2-diethylamino-4-chloro-5-nitrothiazole of melting point 85° C. (from cyclohexane) are obtained.

Workup

  1. waitAfter the mixture has been left
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-6eb0595e77504c47ac161255bd80ecc5
Source dataset
uspto-grants-1991_12
Patent number
US05075326

Reaction notes

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