2,4-Dichloro-5-nitro-1,3-thiazole → HCID 19980553, compound

HRID 1461369Notes

Reaction equation

HRID 1461369 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.Cl[C:8]1[S:9][C:10]([N+:14]([O-:16])=[O:15])=[C:11]([Cl:13])[N:12]=1>CN1CCCC1=O>[Cl:13][C:11]1[N:12]=[C:8]([N:4]2[CH:5]=[CH:6][C:2]([CH3:1])=[N:3]2)[S:9][C:10]=1[N+:14]([O-:16])=[O:15]

Participants

4

Reactant 2

HCID 138518172,4-Dichloro-5-nitro-1,3-thiazoleHCID 178428694HCID 178428694, compound

Product 1

HCID 19980553HCID 19980553, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

4.1 g (0.05 mol) of 3-methylpyrazole are added to a solution of 5.0 g (0.025 mol) of 2,4-dichloro-5-nitrothiazole in 50 ml of N-methyl-2-pyrrolidinone at room temperature. After the mixture has been left to stand at room temperature for four days, it is stirred into 500 ml of ice-water and the precipitate is filtered off, washed with water and dried. 5.8 g (94.9% of theory) of 4-chloro-2-(3-methyl-1-pyrazolyl)-5-nitrothiazole of melting point 153° C. are obtained.

Workup

  1. waitAfter the mixture has been left
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-78dafcc03d5b49e78b73276a0b2c039b
Source dataset
uspto-grants-1991_12
Patent number
US05075326

Reaction notes

Loading…