Trimethyltin chloride → HCID 15030321, compound

HRID 1461392Notes

Reaction equation

HRID 1461392 reaction equation
Br[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.C([Li])CCC.[CH3:21][Sn:22](Cl)([CH3:24])[CH3:23]>CCOCC>[F:9][C:8]([F:11])([F:10])[C:6]1[CH:7]=[C:2]([Sn:22]([CH3:24])([CH3:23])[CH3:21])[CH:3]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:5]=1

Participants

5

Reactant 3

HCID 14016Trimethyltin chlorideHCID 150303204-Bromo-2,6-bis(trifluoromethyl)pyridineHCID 178418339Butyllithium

Product 1

HCID 15030321HCID 15030321, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2,6-Di(trifluoromethyl)-4-(trimethylstannyl)pyridine was prepared from 8.7 g 4-bromo-2,6-di(trifluoromethyl)pyridine, 12.4 ml butyllithium (24M in hexane) and 6 g trimethyltin chloride in 200 ml ether according to the procedure of Example 3, part (g), and was obtained (11 g) as a yellow semi-solid.

Workup

  1. customwas obtained (11 g) as a yellow semi-solid

Sources & evidence

ORD record
ord-0b987bf516d24f168c729342304deb79
Source dataset
uspto-grants-1991_12
Patent number
US05075319

Reaction notes

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