反应详情

To a solution of (3S,4R)-3-[(1R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1R)-3-hydroxy-1,3-dimethyl-2-oxobutyl]-2-azetidinone (135 mg) in tetrahydrofuran (4 ml) was added 1M solution of sodium periodate buffered with acetic acid (mole ratio 1:1) (7.8 ml) at room temperature and the mixture was stirred for 1 day at the same temperature. The reaction mixture was evaporated, acidified, and extracted twice with dichloromethane. The organic layer was washed twice with brine, dried over magnesium sulfate and evaporated to give (2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid (85 mg).

1. customThe reaction mixture was evaporated
2. extractionextracted twice with dichloromethane
3. washThe organic layer was washed twice with brine
4. dry with materialdried over magnesium sulfate
5. customevaporated