HuagongsheHuagongshe Chemistry Print Report · For research reference only
Deferoxamine Mesylate → N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxo-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-butanediamide; zinc
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Deferoxamine Mesylate | HCID 62881 | — |
| Reactant | Zincchloride | HCID 3007855 | — |
| Solvent | HCID 178419078 | HCID 178419078 | — |
| Product | N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxo-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-butanediamide; zinc | HCID 473262 | — |
Reaction Steps
10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 12.5 mM of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, with 10 ml of 5.5 mM Histidine, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed, the ratio Zn:Desferal is 1.25:1.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05075469 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-26de9b2d71084f0e962752e0494ccccd |
| Source note | uspto-grants-1991_12 |