Deferoxamine Mesylate → N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxo-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-butanediamide; zinc

HRID 1461556Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1461556
[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3].CS(O)(=O)=O.[Cl-].[Cl-].[Zn+2:47]>N[C@H](C(O)=O)CC1N=CNC=1>[Zn:47].[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3]

Komponenten

4

Edukt 2

HCID 62881Deferoxamine MesylateHCID 3007855Zincchloride

Produkt 1

HCID 473262N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxo-butanoyl]-hydroxy-amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxy-butanediamide; zinc

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178419078HCID 178419078, VerbindungLösungsmittel

Versuchsvorschrift

10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 12.5 mM of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, with 10 ml of 5.5 mM Histidine, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed, the ratio Zn:Desferal is 1.25:1.0

Aufarbeitung

  1. temperatureThe mixture is heated for 30 min. to 45° C.
  2. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-26de9b2d71084f0e962752e0494ccccd
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05075469

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