HRID1461556

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O

HCID62881

Deferoxamine mesylate

C26H52N6O11S

HCID3007855

Zinc chloride

Cl2Zn

PRODUCTS

生成物

结构：CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.[Zn]

HCID473262

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID178419078

未命名化合物

PROCEDURE

实验过程

10 mM solution of Desferal (Ciba-Geigy, Basle) is mixed with an equal volume of 12.5 mM of ZnCl2 (A. R. Aldrich Chemical Co., Inc.) solution, with 10 ml of 5.5 mM Histidine, titrated to pH 7.4. The mixture is heated for 30 min. to 45° C., and cooled and the complex Zn/Desferrioxamine B is formed, the ratio Zn:Desferal is 1.25:1.0

WORKUP

后处理

temperatureThe mixture is heated for 30 min. to 45° C.
temperaturecooled

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-26de9b2d71084f0e962752e0494ccccd
来源数据集: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05075469
来源说明: uspto-grants-1991_12

反应 SMILES

[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3].CS(O)(=O)=O.[Cl-].[Cl-].[Zn+2:47]>N[C@H](C(O)=O)CC1N=CNC=1>[Zn:47].[CH3:1][C:2]([N:4]([OH:39])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([CH2:13][CH2:14][C:15]([N:17]([OH:38])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([CH2:26][CH2:27][C:28]([N:30]([OH:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])=[O:29])=[O:25])=[O:16])=[O:12])=[O:3]