反应详情

195.4 g (0.9 mol) of N-benzal-2,4-difluoroaniline are dissolved in 900 ml of tetrahydrofuran in an autoclave. 19 g of Raney nickel and 2 g of acetic acid are added, and the mixture is hydrogenated at 60° to 85° C. and a hydrogen pressure of 100 bar. The end point of the reaction is determined by thin-layer chromatography or gas chromatography. The suspension is filtered and the solution is evaporated on a vacuum rotary evaporator. The residue is distilled in vacuo at 102° C. and 3.6 mbar, to give 125.6 g (64% of theory) of a pale yellow liquid.

1. customis hydrogenated at 60° to 85° C.
2. filtrationThe suspension is filtered
3. customthe solution is evaporated on a vacuum rotary evaporator
4. distillationThe residue is distilled in vacuo at 102° C.
5. custom3.6 mbar, to give 125.6 g (64% of theory) of a pale yellow liquid