4-Fluoro-4'-hydroxybiphenyl → Rac-4-[2-fluoro-2-(4'-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:15])[CH:12](Cl)[F:13])=[CH:8][S:7][CH:6]=1)=[O:4].[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>>[F:13][CH:12]([O:29][C:26]1[CH:25]=[CH:24][C:23]([C:20]2[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=2)=[CH:28][CH:27]=1)[C:11]([NH:10][C:9]1[C:5]([C:3]([OH:2])=[O:4])=[CH:6][S:7][CH:8]=1)=[O:15]Komponenten
3
Versuchsvorschrift
In analogy to Example 2, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 4-fluoro-4′-hydroxybiphenyl. MS (m/e): 388.2 (M−H).
Quellen und Nachweise
- ORD-Eintrag
- ord-cdfd5a0361c44990bc9d91a1987e4e5e
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07732452B2
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