HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-4'-hydroxybiphenyl → Rac-4-[2-fluoro-2-(4'-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-4'-hydroxybiphenyl | HCID 345420 | — |
| Reactant | 4-(2-Chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester | HCID 68689462 | — |
| Product | Rac-4-[2-fluoro-2-(4'-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid | HCID 16068686 | — |
Reaction Steps
In analogy to Example 2, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 4-fluoro-4′-hydroxybiphenyl. MS (m/e): 388.2 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732452B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-cdfd5a0361c44990bc9d91a1987e4e5e |
| Source note | uspto-grants-2010_06 |