2-Aminophenol → HCID 19878522, compound

HRID 1461625Notes

Reaction equation

HRID 1461625 reaction equation
[P:1](Cl)(Cl)[O:2][C:3]1[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:7][C:6]([C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:5][C:4]=1[C:17]([CH3:20])([CH3:19])[CH3:18].[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[OH:30].C(N(CC)CC)C>C(Cl)Cl>[C:17]([C:4]1[CH:5]=[C:6]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:7]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:3]=1[O:2][P:1]1[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30]1)([CH3:20])([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 58012-AminophenolHCID 8471TriethylamineHCID 13684698HCID 13684698, compound

Product 1

HCID 19878522HCID 19878522, compoundYield 26.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the general procedure of Example 1, 12.0 g (33 mmol) of 2,4,6-tri-tert-butylphenyl phosphorodichloridite, 3.6 g (33 mmol) of 2-aminophenol, 9.3 ml (66 mmol) of triethylamine and 75 ml of methylene chloride are reacted to give 3.5 g of the title compound as an off-white solid.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-dd35d206e6cf46af8fa06fb93cf87151
Source dataset
uspto-grants-1991_12
Patent number
US05075483

Reaction notes

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