反应详情

To the mixture of 1.62 g of 2-[2-(3-chlorophenyl) propen 3-yl]-2-ethylindan-1,3-dione, 0.34 g of sodium acetate trihydrate and 10 ml of chloroform was added-2.85 g of 40% peracetic acid. After refluxing for 3 hours, excess peroxide was decomposed with 10% sodium thiosulfate aqueous solution, and the organic layer was washed with water, neutralized with a saturated sodium bicarbonate aqueous solution, washed with water and with a saturated saline solution, and dried over anhydrous magnesium sulfate. After the solvent was evaporated, the residue was separated and purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=4/1) to obtain 1.27 g of the compound No. 53 shown in Table 2.

1. temperatureAfter refluxing for 3 hours
2. washthe organic layer was washed with water
3. washwashed with water and with a saturated saline solution
4. dry with materialdried over anhydrous magnesium sulfate
5. customAfter the solvent was evaporated
6. customthe residue was separated
7. custompurified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=4/1)