反应详情

To the mixture of 1.53 g of 2-(2,3-epoxy-2-phenylpropyl)-2-ethylindan-1,3-dione, 15 ml of chloroform and 1 ml of dimethylformamide, was added 0.96 g of pyridine hydrobromide. After refluxing under heating for 6 hours, the reaction mixture was poured into water and was added 20 ml of chloroform. The organic layer was washed with water and with a saturated saline solution, and dried over anhydrous magnesium sulfate. After evaporating the solvent, the residue was separated and purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=4/1) to obtain 0.45 g of the compound No. 36 shown in Table 2.

1. temperatureAfter refluxing
2. temperatureunder heating for 6 hours
3. washThe organic layer was washed with water and with a saturated saline solution
4. dry with materialdried over anhydrous magnesium sulfate
5. customAfter evaporating the solvent
6. customthe residue was separated
7. custompurified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=4/1)