Hydrochloric Acid → 2-(3,5-dichlorophenyl)propan-2-amine

HRID 1461651Notes

Reaction equation

HRID 1461651 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH:8]C=O)([CH3:7])[CH3:6].Cl.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH2:8])([CH3:6])[CH3:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15754135N-(3,5-dichloroalpha,alpha-dimethylbenzyl)formamide

Product 1

HCID 111950522-(3,5-dichlorophenyl)propan-2-amineYield 98%

Procedure

A mixture of 1.16 g (5 mmol) of N-(3,5-dichloroα,α-dimethylbenzyl)formamide and 8 ml of 2N hydrochloric acid was refluxed for 30 minutes. After cooling, the reaction solution was alkalified with a sodium hydroxide aqueous solution and extracted with diethyl ether. The ether solution was washed with water, dried and then concentrated to obtain 1.0 g (yield: 98.0%) of the desired compound.

Workup

  1. temperaturewas refluxed for 30 minutes
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. washThe ether solution was washed with water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-e47868ddba874da7bb8fc5056ec5a666
Source dataset
uspto-grants-1991_12
Patent number
US05076834

Reaction notes

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