Water → 4-Methoxybenzohydrazide

HRID 1461680Notes

Reaction equation

HRID 1461680 reaction equation
O.[NH2:2][NH2:3].C([C:6]1([O:15][CH3:16])[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][CH2:7]1)C.O>C(O)C>[CH3:16][O:15][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH:2][NH2:3])=[O:11])=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 67946003HCID 67946003, compound

Product 1

HCID 767924-MethoxybenzohydrazideYield 64.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

303 g of hydrazine hydrate was added to a solution of 150 g of p-ethylanisic acid in 300 ml of ethanol, followed by heat-refluxing for 20 hours. After the reaction, the reaction mixture was poured into 1.5 liters of iced water to precipitate a crystal. The crystal was recrystallized from ethanol to obtain 88.2 g of 4-methoxybenzohydrazide.

Workup

  1. temperatureby heat-refluxing for 20 hours
  2. customAfter the reaction
  3. customto precipitate a crystal
  4. customThe crystal was recrystallized from ethanol

Sources & evidence

ORD record
ord-2978243bfe3f4e5dac3e41b762942f06
Source dataset
uspto-grants-1991_12
Patent number
US05076961

Reaction notes

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