Hydrochloric Acid → HCID 178418664, compound

HRID 1461698Notes

Reaction equation

HRID 1461698 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[SH:15])=O)(C)(C)C.[ClH:16]>C(O)(=O)C>[ClH:16].[NH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[SH:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178418597HCID 178418597, compound

Product 1

HCID 178418664HCID 178418664, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A 13.78 g (0.06 mol) sample of 3-(t-butyloxycarbonyl)amino-4-mercapto pyridine was dissolved with acetic acid (250 mL) and added to an ice cold solution of ~3N HCl in acetic acid which had been made by bubbling HCl(g) through glacial acetic acid (100 mL). After about four hours the resulting solid was filtered, washed with diethyl ether and dried in vacuo to yield 10.4 g (~100%) of the title compound.

Workup

  1. customby bubbling HCl(g) through glacial acetic acid (100 mL)
  2. filtrationAfter about four hours the resulting solid was filtered
  3. washwashed with diethyl ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-258d4c583b564596be89f6b94e2090a7
Source dataset
uspto-grants-1991_12
Patent number
US05077287

Reaction notes

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