Potassium Hydroxide → HCID 14851349, compound

HRID 1461723Notes

Reaction equation

HRID 1461723 reaction equation
[CH2:1]1[CH:6]([C:7]([OH:20])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:5][CH2:4][NH:3][CH2:2]1.[OH-].[K+].[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32]Cl)=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[OH:20][C:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH:6]1[CH2:5][CH2:4][N:3]([CH2:32][CH2:31][C:28]2[CH:29]=[CH:30][C:25]([O:24][CH3:23])=[CH:26][CH:27]=2)[CH2:2][CH2:1]1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 15723AzacyclonolHCID 875134-(2-Chloroethyl)phenyl methyl ether

Product 1

HCID 14851349HCID 14851349, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4 g of α,α-diphenyl-4-piperidinomethanol, 0.94 g of powdered potassium hydroxide and 200 mg of KI are dispersed in 50 ml of toluene in a 250 ml round-bottomed flask. Addition of 2.3 ml of 4-methoxyphenylethyl chloride is followed by heating under reflux for 3 days.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 3 days

Sources & evidence

ORD record
ord-612bd3f9f92541a79a3d4b64bffe5a14
Source dataset
uspto-grants-1991_12
Patent number
US05077301

Reaction notes

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