4-(Dimethylamino)butyronitrile → HCID 14882752, compound

HRID 1461735Notes

Reaction equation

HRID 1461735 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][C:7]#[N:8])[CH3:3].[Cl:9][CH2:10][CH2:11][CH2:12]I>>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([CH2:12][CH2:11][CH2:10][Cl:9])[C:7]#[N:8])[CH3:3]

Participants

3

Reactant 2

HCID 564304-(Dimethylamino)butyronitrileHCID 813631-Chloro-3-iodopropane

Product 1

HCID 14882752HCID 14882752, compound

Procedure

The amine of formula III, when n is equal to 3, p equal to 2 and q equal to zero, is prepared from 4-(N,N-dimethylamino)butyronitrile. This compound is condensed with 3-chloro-l-iodopropane to form 2-[2-(N,N-dimethylamino) ethyl]-5-chloropentanenitrile which, after cyclization, gives 4-cyano-l-methylperhydroazepine. From this compound and using conventional methods, the expected amine is obtained.

Sources & evidence

ORD record
ord-c40892b5a88b46879a73586a90e7cdde
Source dataset
uspto-grants-1991_12
Patent number
US05077288

Reaction notes

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