Potassium Iodide → HCID 178432285, compound

HRID 1461745Notes

Reaction equation

HRID 1461745 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([CH:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[Cl:17][CH2:18][CH2:19][C:20]1[C:21]([CH3:32])=[N:22][C:23]2[N:24]([CH:27]=[N:28][C:29]=2[C:30]#[N:31])[C:25]=1[OH:26].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CC(C)CC(=O)C>[ClH:17].[C:30]([C:29]1[N:28]=[CH:27][N:24]2[C:25]([OH:26])=[C:20]([CH2:19][CH2:18][N:11]3[CH2:12][CH2:13][CH2:14][CH:8]([C:6](=[O:7])[C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:16][CH:15]=4)[CH2:9][CH2:10]3)[C:21]([CH3:32])=[N:22][C:23]=12)#[N:31]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 14674208HCID 14674208, compoundHCID 178432280HCID 178432280, compound

Product 1

HCID 178432285HCID 178432285, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

The compound obtained in Stage F, 9.7 g of 3-(2-chloroethyl)-8-cyano-4-hydroxy-2-methylimidazo[1,5-a]-pyrimidine, 23 g of sodium carbonate, 0.5 g of potassium iodide and 800 ml of 4-methyl-2-pentanone are brought to reflux. The procedure then adopted is as described in Example 1, Stage C, to obtain the expected hydrochloride.

Workup

  1. temperatureto reflux

Sources & evidence

ORD record
ord-4ab95b1d342244bdb45a25a5dccb4b52
Source dataset
uspto-grants-1991_12
Patent number
US05077288

Reaction notes

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