Tert-Butylamine → HCID 19979380, compound

HRID 1461768Notes

Reaction equation

HRID 1461768 reaction equation
[CH:1]([C:4]1[C:9]([N:10]=[C:11]=[S:12])=[C:8]([CH:13]([CH3:15])[CH3:14])[CH:7]=[C:6]([O:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:5]=1)([CH3:3])[CH3:2].[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25]>C1(C)C=CC=CC=1>[C:24]([NH:28][C:11]([NH:10][C:9]1[C:4]([CH:1]([CH3:2])[CH3:3])=[N:5][C:6]([O:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)=[CH:7][C:8]=1[CH:13]([CH3:15])[CH3:14])=[S:12])([CH3:27])([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 19979372HCID 19979372, compound

Product 1

HCID 19979380HCID 19979380, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

8.15 g of 2,4-diisopropyl-6-(4-chlorophenoxy)-pyrid-3-yl isothiocyanate are diluted with 30 ml of toluene, and 2.0 g of tert.-butylamine are added dropwise. The reaction mixture is then further stirred for 2 hours at approximately +60° C. The reaction mixture is concentrated and hexane is added to the residue. The resulting solid is filtered off and subsequently washed with hexane. 1-tert.-Butyl-3-[2,4-diisopropyl-6-(4-chlorophenoxy)-pyrid-3-yl]-thiourea is obtained in the form of colourless crystals, m.p. 165°-167° C.

Workup

  1. additionare added dropwise
  2. concentrationThe reaction mixture is concentrated
  3. additionhexane is added to the residue
  4. filtrationThe resulting solid is filtered off
  5. washsubsequently washed with hexane

Sources & evidence

ORD record
ord-1d746c1904ac43b695e41ce965d9c635
Source dataset
uspto-grants-1991_12
Patent number
US05077304

Reaction notes

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