HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 4-bromo- → 4-(8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 4-bromo- | HCID 12162 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-6-one | HCID 12348074 | — |
| Reactant | Tetrahydrofuran hexane | HCID 21883165 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 4-(8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)benzonitrile | HCID 15023905 | 70% |
Reaction Steps
4-Bromobenzonitrile was treated in THF-hexane with n-butyllithium at -100° C. Cyclohexanedione monoethylene ketal was added at -100° to give 70% yield of 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05077404 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-83fccd9e25934bc7b89a55d5fce0a6c0 |
| Source note | uspto-grants-1991_12 |