Formaldehyde → Dimethyl {[benzyl(hydroxy)amino]methyl}phosphonate

Participants

Reaction Conditions

Reaction Steps

Using the procedure of Example 1, the above-named compound is prepared from 5.0 g (31 mmol) of N-benzylhydroxylamine hydrochloride, 1.8 g (60 mmol) of paraformaldehyde, 3.7 ml (40 mmol) of dimethyl phosphite, 2.5 g (30 mmol) of sodium bicarbonate and 350 ml of THF by heating at 55° C. for seven hours. The residue is purified by column chromatography (silica gel, methylene chloride: ethyl acetate eluent) to give 6.1 g (80% yield) of a viscous colorless liquid.

Provenance & Evidence