Trifluoroacetic acid → HCID 15730213, compound

HRID 1461878Notes

Reaction equation

HRID 1461878 reaction equation
CC(C)(OC([NH:7][O:8][CH2:9][C:10]([NH:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[C:19]([S:21]([OH:24])(=[O:23])=[O:22])[CH:18]=[C:17]([OH:25])[C:16]=1[OH:26])=[O:11])=O)C.FC(F)(F)C(O)=O>ClCCl.CCOCC>[NH2:7][O:8][CH2:9][C:10]([NH:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[C:19]([S:21]([OH:24])(=[O:22])=[O:23])[CH:18]=[C:17]([OH:25])[C:16]=1[OH:26])=[O:11]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15730212HCID 15730212, compound

Product 1

HCID 15730213HCID 15730213, compoundYield 124.5%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A suspension of 2,3-dihydroxy-5-sulfobenzoic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]aminooxy]acetyl]hydrazide (1.3 g, 3.0 mmole) in 10 ml of dichloromethane at -10° C. was treated dropwise with 10 ml of trifluoroacetic acid. The mixture was allowed to warm to room temperature and was stirred for 2 hours. The mixture was diluted with 30 ml of ether and filtered to give 1.2 g of a white solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-4dd43393efac40e58f9e2f44e11f85da
Source dataset
uspto-grants-1991_12
Patent number
US05077432

Reaction notes

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