反应详情

A mixture of 14.6 g of 4-methyl-1-(3-nitrophenyl)-1H-imidazole, 766 mg of palladium black, 19.6 g of sodium formate, 12.8 ml of formic acid in 300 ml of methyl alcohol is stirred for 18 hours under a hydrogen atmosphere. The mixture is filtered through diatomaceous earth and the filtrate evaporated to a residue. The residue is partitioned between saturate potassium bicarbonate and chloroform. The organic layer is dried and evaporated to a residue which is dissolved in a minimum of chloroform and passed through a pad of hydrous magnesium silicate. The filtrate is evaporated to a residue which is stirred with ether and the resulting solid filtered and air dried to give 10.3 g of the desired product as a solid, m.p. 117°-119° C.

1. filtrationThe mixture is filtered through diatomaceous earth
2. customthe filtrate evaporated to a residue
3. customThe residue is partitioned
4. concentrationbetween saturate potassium bicarbonate and chloroform
5. customThe organic layer is dried
6. customevaporated to a residue which
7. dissolutionis dissolved in a minimum of chloroform
8. customThe filtrate is evaporated to a residue which
9. stirringis stirred with ether
10. filtrationthe resulting solid filtered
11. customair dried