HRID1461930

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11417

3,4-Dimethylpyridine

C7H9N

结构：CCCCCCCCCCCCCCOc1ccc(CC(=O)Nc2cccc(CBr)c2)cc1

HCID10052253

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(CC(=O)Nc2cccc(C[n+]3ccc(C)c(C)c3)c2)cc1.[Br-]

HCID15030146

未命名化合物

收率 82.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A mixture of 1.5 g of N-[3-(bromomethyl)phenyl]-4-(tetradecyloxy)benzeneacetamide and 933.5 mg of 3,4-lutidine in 25 ml of acetonitrile is refluxed under argon for 4 hours. The solvent is evaporated and the residue mixed with ether. The solid is collected via centrifugation, washed with ether several times and vacuum dried to give 1.5 g of the desired product as a gray-white powder, m.p. 125°-128° C.

WORKUP

后处理

temperatureis refluxed under argon for 4 hours
customThe solvent is evaporated
additionthe residue mixed with ether
customThe solid is collected via centrifugation
washwashed with ether several times and vacuum
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-66a08f58518e45e3a18977d79cb5908a
来源数据集: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05077409
来源说明: uspto-grants-1991_12

反应 SMILES

[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:33])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1.[N:34]1[CH:39]=[CH:38][C:37]([CH3:40])=[C:36]([CH3:41])[CH:35]=1>C(#N)C>[Br-:1].[CH3:41][C:36]1[CH:35]=[N+:34]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][C:10](=[O:33])[CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:14][CH:13]=3)[CH:4]=2)[CH:39]=[CH:38][C:37]=1[CH3:40]