反应详情

875 g of ethyl 3,3,5-trimethyl-cyclohexylacetate are treated in 2.2 l of water with 670 g of 30% sodium hydroxide and the mixture is held at reflux temperature for 21/2 hours while stirring. After cooling, the mixture is neutralized, acidified with 420 g of 63% sulphuric acid and extracted with cyclohexane. The cyclohexane extract is washed neutral, evaporated and the 770 g of crude product are distilled. There are obtained 630 g of 3,3,5-trimethyl-cyclohexylacetic acid. (Yield: 82%).

1. temperatureat reflux temperature for 21/2 hours
2. temperatureAfter cooling
3. extractionextracted with cyclohexane
4. extractionThe cyclohexane extract
5. washis washed neutral
6. customevaporated
7. distillationthe 770 g of crude product are distilled