Methanol → 2-(3,5-Dimethylcyclohexyl)acetic acid

HRID 1461955Notes

Reaction equation

HRID 1461955 reaction equation
[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][CH:4]([CH2:9][C:10]([O:12]CC)=[O:11])[CH2:3]1.CO.[OH-].[K+]>O>[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][CH:4]([CH2:9][C:10]([OH:12])=[O:11])[CH2:3]1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 20454256Ethyl 3,5-dimethyl-cyclohexylacetate

Product 1

HCID 204542532-(3,5-Dimethylcyclohexyl)acetic acidYield 92.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

44.7 g of ethyl 3,5-dimethyl-cyclohexylacetate are treated with 300 ml of methanol and 15 g of potassium hydroxide, dissolved in 140 ml of water, and saponified by heating to reflux temperature for 3 hours. The working-up yields 35.6 g of a solid crude product which is used directly. A sample is distilled for the purpose of analysis.

Workup

  1. temperaturesaponified by heating
  2. temperatureto reflux temperature for 3 hours

Sources & evidence

ORD record
ord-0e1b52d2bf2e46028835f48ad4fda108
Source dataset
uspto-grants-1984_07
Patent number
US04457862

Reaction notes

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