HRID1461985

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：C[C@H]1CC(=O)C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@]21C

HCID15020

Mesterolone

C20H32O2

PRODUCTS

生成物

结构：C[C@H]1CC2(C[C@@H]3CC[C@H]4[C@@H]5CC[C@H](O)[C@@]5(C)CC[C@@H]4[C@]31C)OCCO2

HCID13020861

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID174

Ethylene glycol

C2H6O2

溶剂HCID1140

Toluene

C7H8

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

A solution of 30 g of 17β-hydroxy-1α-methyl-5α-androstan-3-one in 300 ml of toluene and 90 ml of ethylene glycol is combined with 900 mg of p-toluenesulfonic acid and stirred for 6 hours with gradual removal by distillation. After cooling, the reaction solution is mixed with 3 ml of pyridine, diluted with diethyl ether, and washed with water. After evaporation, 35 g of 3,3-ethylenedioxy-1α-methyl-5α-androstan-17β-ol is obtained.

WORKUP

后处理

temperatureAfter cooling
washwashed with water
customAfter evaporation