2-Chlorobenzamide → N-(2,4-Difluoro-3,5-dichlorophenyl)-N'-(2-chlorobenzoyl)-urea

HRID 1462013Notes

Reaction equation

HRID 1462013 reaction equation
[F:1][C:2]1[C:7]([Cl:8])=[C:6]([F:9])[C:5]([Cl:10])=[CH:4][C:3]=1[N:11]=[C:12]=[O:13].[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[C:17]([NH2:19])=[O:18]>C1(C)C(C)=CC=CC=1>[F:1][C:2]1[C:7]([Cl:8])=[C:6]([F:9])[C:5]([Cl:10])=[CH:4][C:3]=1[NH:11][C:12]([NH:19][C:17](=[O:18])[C:16]1[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=1[Cl:14])=[O:13]

Participants

4

Reactant 2

HCID 691112-ChlorobenzamideHCID 140475992,4-Difluoro-3,5-dichlorophenyl isocyanate

Product 1

HCID 13051730N-(2,4-Difluoro-3,5-dichlorophenyl)-N'-(2-chlorobenzoyl)-urea

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 9.0 gm (0.040 mol) of 2,4-difluoro-3,5-dichlorophenyl isocyanate, 6.5 gm (0.042 mol) of 2-chlorobenzamide, and 100 ml of xylene was boiled for five hours under reflux. It was then allowed to cool, and the product which precipitated was removed by suction filtration and dried.

Workup

  1. temperatureunder reflux
  2. temperatureto cool
  3. customthe product which precipitated
  4. customwas removed by suction filtration
  5. customdried

Sources & evidence

ORD record
ord-dd590b7df1594f09b8351ea1e34afe0c
Source dataset
uspto-grants-1984_07
Patent number
US04457943

Reaction notes

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