HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 1-Phenyl-4-(2-morpholinoethyl)-2-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4-(2-Chloroethyl)morpholine | HCID 76727 | — |
| Reactant | 2-Methyl-1-phenylpiperazine | HCID 98086 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Phenyl-4-(2-morpholinoethyl)-2-methylpiperazine | HCID 20454475 | — |
Reaction Steps
In the same manner as described in Example 1, N-(2-chloroethyl)morpholine is reacted with 1-phenyl-2-methylpiperazine. The trihydrochloride has a melting point 288°-290° (from methanol); Rf=0.63 (MeOH-conc. NH4OH 97:3); IR (nujol) νmax: 2420, 1500, 1405, 1265, 1060, 770, 695 cm-1 ; 1H-NMR (D2O; (CH3)3Si(CD2)2COONa): 1.05 (d, J=6 Hz; 3H; 2.70-4.20 (m; 19H); 7.47 (s; 5H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04457931 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-297fb8eb6d624011a2fa8f3c9f168f3e |
| Source note | uspto-grants-1984_07 |