Ammonium Hydroxide → 1-Phenyl-4-(2-morpholinoethyl)-2-methylpiperazine

HRID 1462023Notes

Reaction equation

HRID 1462023 reaction equation
Cl[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1.[C:10]1([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH:17]2[CH3:22])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[NH4+].[OH-]>CO>[C:10]1([N:16]2[CH2:21][CH2:20][N:19]([CH2:2][CH2:3][N:4]3[CH2:9][CH2:8][O:7][CH2:6][CH2:5]3)[CH2:18][CH:17]2[CH3:22])[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 767274-(2-Chloroethyl)morpholineHCID 980862-Methyl-1-phenylpiperazine

Product 1

HCID 204544751-Phenyl-4-(2-morpholinoethyl)-2-methylpiperazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

In the same manner as described in Example 1, N-(2-chloroethyl)morpholine is reacted with 1-phenyl-2-methylpiperazine. The trihydrochloride has a melting point 288°-290° (from methanol); Rf=0.63 (MeOH-conc. NH4OH 97:3); IR (nujol) νmax: 2420, 1500, 1405, 1265, 1060, 770, 695 cm-1 ; 1H-NMR (D2O; (CH3)3Si(CD2)2COONa): 1.05 (d, J=6 Hz; 3H; 2.70-4.20 (m; 19H); 7.47 (s; 5H).

Sources & evidence

ORD record
ord-297fb8eb6d624011a2fa8f3c9f168f3e
Source dataset
uspto-grants-1984_07
Patent number
US04457931

Reaction notes

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