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HRID1462121

反应详情

EQUATION

反应方程式

HRID 1462121 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CCCCCCCCCCCCCCCCCC(=O)Cl
HCID8212

Octadecanoyl chloride

C18H35ClO

结构：C[Si](C)(C)C(C(N)=O)[Si](C)(C)C
HCID11708267

Bistrimethylsilylacetamid

C8H21NOSi2

结构：COC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)OC(C)(C)C
HCID131713573

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCCCCCCCCCCCCCC(=O)N[C@@H](C)C(=O)N[C@H](CCC(=O)O)C(=O)OCc1ccccc1
HCID131713574

未命名化合物

收率 196.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

L-Ala-D-Glu(OH)OBzl (1) (942 mg) was suspended in methylene chloride (40 ml), and bis(trimethylsilyl)acetamide (1.20 g) was added to the suspension under stirring. The resulting solution was treated with stearoyl chloride (900 mg) at ambient temperature and left for an hour. Evaporation of the solvent gave an oily residue which was treated with water to give white solids. The solids were collected by filtration, washed with water and dried over magnesium sulfate to give stearoyl-L-Ala-D-Glu(OH)OBzl (2) (1.60 g).

WORKUP

后处理

  1. waitleft for an hour
  2. customEvaporation of the solvent
  3. customgave an oily residue which
  4. customto give white solids
  5. filtrationThe solids were collected by filtration
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate