Ethylamine → HCID 13337006, compound

HRID 1462297Notes

Reaction equation

HRID 1462297 reaction equation
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[N:4]=1)#[N:2].[CH2:19]([NH2:21])[CH3:20]>O1CCCC1>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([NH:21][CH2:19][CH3:20])=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[N:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 12907209HCID 12907209, compound

Product 1

HCID 13337006HCID 13337006, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

2,3-Dicyano-5-chloro-6-(m-bromophenyl)pyrazine (1.15 g; 0.0036 mole) was dissolved in 20 ml of tetrahydrofuran. The solution was cooled to 0° C., and 0.50 g of a 70% aqueous solution of ethylamine was added. The mixture was worked up in the same way as in Example 13, and recrystallized from ethanol to afford 0.95 g (yield 80%) of 2,3-dicyano-5-ethylamino-6-(m-bromophenyl)pyrazine.

Workup

  1. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-22403776a63b47c7a9526f4cb3fa39de
Source dataset
uspto-grants-1984_07
Patent number
US04460403

Reaction notes

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