Pyridine → 2,3-Dicyano-5-chloro-6-ethylthiopyrazine

HRID 1462305Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1462305
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([Cl:12])[N:4]=1)#[N:2].[CH2:13]([SH:15])[CH3:14].N1C=CC=CC=1>CC(C)=O.O>[C:9]([C:8]1[C:3]([C:1]#[N:2])=[N:4][C:5]([Cl:12])=[C:6]([S:15][CH2:13][CH3:14])[N:7]=1)#[N:10]

Komponenten

6

Edukt 3

HCID 1049PyridineHCID 6343EthanethiolHCID 6078205,6-Dichloro-2,3-dicyanopyrazine

Produkt 1

HCID 128737542,3-Dicyano-5-chloro-6-ethylthiopyrazineAusbeute 29,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2,3-Dicyano-5,6-dichloropyrazine (1.00 g; 0.005 mole) and 0.47 g of ethanethiol were dissolved in 50 ml of acetone. The solution was cooled to -15° to -10° C., and a solution of 0.40 g (0.005 mole) of pyridine in 40 ml of water was added dropwise over the period of 30 minutes. The mixture was worked up in the same way as in Example 26 to afford 0.33 g (yield 29%) of 2,3-dicyano-5-chloro-6-ethylthiopyrazine.

Aufarbeitung

  1. temperatureThe solution was cooled to -15° to -10° C.

Quellen und Nachweise

ORD-Eintrag
ord-e45b35f256e542e4923d2ef801e67df9
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04460403

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