Water → HCID 13295055, compound

HRID 1462348Notes

Reaction equation

HRID 1462348 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([Cl:13])=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17].O>C(O)(=O)C>[C:16]([NH:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([Cl:13])=[CH:9][N:8]=2)=[CH:4][CH:3]=1)(=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 13295054HCID 13295054, compound

Product 1

HCID 13295055HCID 13295055, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-(4-Aminophenoxy)-5-chloropyrimidine (20 g), was dissolved in acetic acid (100 ml), and acetic anhydride (20 ml) was added to the solution. After standing for a period of 5 minutes the solution was heated on a steam bath and hot water (100 ml) was slowly added. On cooling the product crystallised and was collected and dried. Yield 20 g, m.p. 202° C.

Workup

  1. temperaturethe solution was heated on a steam bath
  2. temperatureOn cooling the product
  3. customcrystallised
  4. customwas collected
  5. customdried

Sources & evidence

ORD record
ord-f263e038054c4b26a8bf1d9f778bbf0e
Source dataset
uspto-grants-1984_07
Patent number
US04460588

Reaction notes

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