1,2-Dibromoethane → 6-(2-Bromoethoxy)salicylamide

Participants

Reaction Steps

A mixture of 23.0 g of 2,6-dihydroxybenzamide, 20.7 g of potassium carbonate and 28.2 g of 1,2-dibromoethane in 300 ml of acetonitrile is stirred under reflux for 2-3 hours. The reaction mixture is filtered whilst still warm, the filtrate is evaporated and the residue is recrystallised from a little methanol. 6-(2-Bromoethoxy)salicylamide with a melting point of 120°-121° is obtained.

Provenance & Evidence