反应详情

A mixture of 23.0 g of 2,6-dihydroxybenzamide, 20.7 g of potassium carbonate and 28.2 g of 1,2-dibromoethane in 300 ml of acetonitrile is stirred under reflux for 2-3 hours. The reaction mixture is filtered whilst still warm, the filtrate is evaporated and the residue is recrystallised from a little methanol. 6-(2-Bromoethoxy)salicylamide with a melting point of 120°-121° is obtained.

1. temperatureunder reflux for 2-3 hours
2. filtrationThe reaction mixture is filtered
3. temperaturewhilst still warm
4. customthe filtrate is evaporated
5. customthe residue is recrystallised from a little methanol