HCID 10409887, compound → HCID 54115390, compound

HRID 1462361Notes

Reaction equation

HRID 1462361 reaction equation
[C:1]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][N:12](CC2C=CC=CC=2)[CH2:13][CH:14]([OH:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:6][C:5]=1[OH:31])(=[O:3])[NH2:2]>C(O)(C)C>[C:1]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:21])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:6][C:5]=1[OH:31])(=[O:3])[NH2:2]

Participants

3

Reactant 1

HCID 10409887HCID 10409887, compound

Product 1

HCID 54115390HCID 54115390, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

16.6 g of crude N-[3-(4-carbamoyl-3-hydroxyphenoxy)propyl]-N-(2-hydroxy-2-phenyl-ethyl)-benzylamine are hydrogenated analogously to Example 4 and the reaction mixture is worked up. α-[N-[3-(4-Carbamoyl-3-hydroxy-phenoxy)-propyl]-aminomethyl]-benzyl alcohol with a melting point of 208°-210° is obtained by recrystallisation from isopropanol.

Sources & evidence

ORD record
ord-1b197df927994601abd92786feca9e62
Source dataset
uspto-grants-1984_07
Patent number
US04460580

Reaction notes

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