HCID 13105435, compound → HCID 23693741, compound

HRID 1462406Notes

Reaction equation

HRID 1462406 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:19]3[CH:23]=[CH:22][S:21][CH:20]=3)=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[OH-].[K+:25].CO>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:19]3[CH:23]=[CH:22][S:21][CH:20]=3)=[C:11]([CH2:13][C:14]([O-:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[K+:25]

Participants

3

Reactant 2

HCID 13105435HCID 13105435, compoundHCID 23689386Potassium hydroxide methanol

Product 1

HCID 23693741HCID 23693741, compoundYield 80%

Procedure

2.7 g of ethyl 2-[2-(4-fluorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate are dissolved in 10 ml of 10% potassium hydroxide/methanol, and the solution is stirred at room temperature for 17 hours. After the reactioh, the crystalline precipitates are collected by filtration, and then washed with cold ethanol and ether. 2.4 g of potassium 2-[2-(4-fluorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate are thereby obtained.

Workup

  1. customAfter the reactioh, the crystalline precipitates
  2. filtrationare collected by filtration
  3. washwashed with cold ethanol and ether

Sources & evidence

ORD record
ord-893afefeceed4b6396854eac9e46d57d
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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