Thionyl Chloride → n-Pentyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetate

HRID 1462409Notes

Reaction equation

HRID 1462409 reaction equation
[C:1]1([C:7]2[O:8][C:9]([C:16]3[CH:20]=[CH:19][S:18][CH:17]=3)=[C:10]([CH2:12][C:13]([OH:15])=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O>C(O)CCCC>[C:1]1([C:7]2[O:8][C:9]([C:16]3[CH:20]=[CH:19][S:18][CH:17]=3)=[C:10]([CH2:12][C:13]([O:15][CH2:3][CH2:2][CH2:1][CH2:6][CH3:5])=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 131054392-[2-Phenyl-5-(3-thienyl)-4-oxazolyl]acetic acid

Product 1

HCID 13105446n-Pentyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetateYield 40.2%

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Procedure

2 g of 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetic acid, 3 g of thionyl chloride and 30 ml of n-pentanol are treated in the same manner as described in Example 13. One g of n-pentyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetate is thereby obtained. Yield: 40.2%

Sources & evidence

ORD record
ord-4bc1cf56da9f4cfe959a51fa1f9ad354
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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