Hydrochloric Acid → 2-Amino-1-(3-thienyl)ethanone hydrochloride

HRID 1462415Notes

Reaction equation

HRID 1462415 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10]C=[N:8][C:7]=2C(OC)=O)=[CH:2]1.[ClH:15]>>[ClH:15].[S:1]1[CH:5]=[CH:4][C:3]([C:6]([CH2:7][NH2:8])=[O:10])=[CH:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 131054165-(3-Thienyl)-4-methoxycarbonyloxazole

Product 1

HCID 131054172-Amino-1-(3-thienyl)ethanone hydrochlorideYield 91%

Procedure

A mixture of 20.9 g of 5-(3-thienyl)-4-methoxycarbonyloxazole and 100 ml of 6N hydrochloric acid is stirred at 80° to 90° C. for 4 hours. Then, the reaction mixture is condensed under reduced pressure, and the residue is crystallized with acetone. 16.2 g of N-[(3-thienylcarbonyl)methyl]amine hydrochloride are thereby obtained.

Workup

  1. customcondensed under reduced pressure
  2. customthe residue is crystallized with acetone

Sources & evidence

ORD record
ord-0ae5079fad0041a38ef6af454f5be933
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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