HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl 5-(thiophen-2-yl)-1,3-oxazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Thiophenecarbonyl chloride | HCID 78928 | — |
| Reactant | Methyl isocyanoacetate | HCID 547815 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 5-(thiophen-2-yl)-1,3-oxazole-4-carboxylate | HCID 13105420 | 86% |
Reaction Steps
29.7 g of methyl α-isocyanoacetate, 120 g of triethylamine, 450 ml of tetrahydrofuran and 48.4 g of 2-thienylcarbonyl chloride are treated in the same manner as described in Preparation 1-(1). 53.9 g of 5-(2-thienyl)-4-methoxycarbonyloxazole are thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04460596 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-7a3101221e9646ab89edee52884c9a09 |
| Source note | uspto-grants-1984_07 |