HRID1462417

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID78928

2-Thiophenecarbonyl chloride

C5H3ClOS

HCID547815

Methyl isocyanoacetate

C4H5NO2

PRODUCTS

生成物

HCID13105420

Methyl 5-(thiophen-2-yl)-1,3-oxazole-4-carboxylate

C9H7NO3S

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

29.7 g of methyl α-isocyanoacetate, 120 g of triethylamine, 450 ml of tetrahydrofuran and 48.4 g of 2-thienylcarbonyl chloride are treated in the same manner as described in Preparation 1-(1). 53.9 g of 5-(2-thienyl)-4-methoxycarbonyloxazole are thereby obtained.

WORKUP

后处理

customas described in Preparation 1-(1)