Hydrochloric Acid → 2-Amino-1-(thiophen-2-yl)ethan-1-one hydrochloride

HRID 1462418Notes

Reaction equation

HRID 1462418 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10]C=[N:8][C:7]=1C(OC)=O.[ClH:15]>>[ClH:15].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH2:7][NH2:8])=[O:10]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13105420Methyl 5-(thiophen-2-yl)-1,3-oxazole-4-carboxylate

Product 1

HCID 126098332-Amino-1-(thiophen-2-yl)ethan-1-one hydrochlorideYield 93%

Procedure

53.9 g of 5-(2-thienyl)-4-methoxycarbonyloxazole and 200 ml of 6N hydrochloric acid are treated in the same manner as described in Preparation 1-(2). 42.5 g of N-[(2-thienylcarbonyl)methyl]amine hydrochloride are thereby obtained. Yield: 93%

Workup

  1. customas described in Preparation 1-(2)

Sources & evidence

ORD record
ord-e82bf5606a414a3bb259fcda3782b7bd
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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