Ethyl bromoacetate → Ethyl 3-benzoylamino-3-(3-thienylcarbonyl)propionate

HRID 1462422Notes

Reaction equation

HRID 1462422 reaction equation
[C:1]([NH:9][CH2:10][C:11]([C:13]1[CH:17]=[CH:16][S:15][CH:14]=1)=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[C:1]([NH:9][CH:10]([C:11]([C:13]1[CH:17]=[CH:16][S:15][CH:14]=1)=[O:12])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13105427N-benzoyl-N-[(3-thienylcarbonyl)methyl]amine

Product 1

HCID 13105431Ethyl 3-benzoylamino-3-(3-thienylcarbonyl)propionateYield 68%

Procedure

4.7 g of N-benzoyl-N-[(3-thienylcarbonyl)methyl]amine, 1.1 g of 50% sodium hydride and 3.9 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(4). 4.2 g of ethyl 3-benzoylamino-3-(3-thienylcarbonyl)propionate are thereby obtained.

Workup

  1. customas described in Preparation 1-(4)

Sources & evidence

ORD record
ord-66a5e1d1a1544e03bd31eefd591e2a82
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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