HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoyl chloride → 2-[(4-Fluorobenzoylamino)acetyl]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Amino-1-(thiophen-2-yl)ethan-1-one hydrochloride | HCID 12609833 | — |
| Product | 2-[(4-Fluorobenzoylamino)acetyl]thiophene | HCID 13105422 | 94.4% |
Reaction Steps
20.8 g of N-[(2-thienylcarbonyl)methyl]amine hydrochloride, 40.0 g of sodium bicarbonate and 18.5 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(3). 29 g of N-(4-fluorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine are thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04460596 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-548d5c5aeba9493e8fe09530ee935a4b |
| Source note | uspto-grants-1984_07 |