4-Fluorobenzoyl chloride → 2-[(4-Fluorobenzoylamino)acetyl]thiophene

HRID 1462425Notes

Reaction equation

HRID 1462425 reaction equation
Cl.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[F:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:10][CH2:9][C:7]([C:3]2[S:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:22])=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 678794-Fluorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 126098332-Amino-1-(thiophen-2-yl)ethan-1-one hydrochloride

Product 1

HCID 131054222-[(4-Fluorobenzoylamino)acetyl]thiopheneYield 94.4%

Procedure

20.8 g of N-[(2-thienylcarbonyl)methyl]amine hydrochloride, 40.0 g of sodium bicarbonate and 18.5 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(3). 29 g of N-(4-fluorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine are thereby obtained.

Workup

  1. customas described in Preparation 1-(3)

Sources & evidence

ORD record
ord-548d5c5aeba9493e8fe09530ee935a4b
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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