Ethyl bromoacetate → Ethyl 3-(4-chlorobenzoylamino)-3-(2-thienylcarbonyl)propionate

HRID 1462427Notes

Reaction equation

HRID 1462427 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[O:11])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH:9]([C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[O:11])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13105423N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine

Product 1

HCID 13105426Ethyl 3-(4-chlorobenzoylamino)-3-(2-thienylcarbonyl)propionateYield 65.9%

Procedure

5 g of N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine, 1.03 g of 50% sodium hydride and 2.98 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(4). 4.3 g of ethyl 3-(4-chlorobenzoylamino)-3-(2-thienylcarbonyl)propionate are thereby obtained.

Workup

  1. customas described in Preparation 1-(4)

Sources & evidence

ORD record
ord-34d543f3505840c3946788114da55f62
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

Loading…