HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Methyl 3-(4-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | N-(4-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amine | HCID 13105428 | — |
| Product | Methyl 3-(4-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate | HCID 13345231 | 64.3% |
Reaction Steps
23 g of N-(4-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amine, 6.1 g of 50% sodium hydride and 21.8 g of methyl bromoacetate are treated in the same manner as described in Preparation 1-(4). 18.6 g of methyl 3-(4-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate are thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04460596 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-3cb2f8f29aaa4bcc83289eda39117c6a |
| Source note | uspto-grants-1984_07 |